Essential Biology for Medicinal Chemists

Scientific Update

Short course

In Mayfield

Price on request

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Description

  • Type

    Short course

  • Location

    Mayfield

The objectives of the course are: An improved knowledge of current biological technology relevant to your everyday work. An increased understanding of biological data handling, the order in which it appears and its value in progressing their compounds. An enhanced appreciation of the biology of the major drug target protein classes. Overall, an improved ability to merge chemical and biological data to generate drug. discovery knowledge. Suitable for: Chemists who have recently started in the pharmaceutical industry as medicinal. chemists. Project Managers with a medicinal chemistry background who wish to gain a. better understanding of biological aspects of their drug discovery projects. Experienced medicinal chemists who wish to gain a deeper knowledge of the. biological context of their work. Students who are planning a career in industry and can obtain company sponsorship.

Facilities

Location

Start date

Mayfield (East Sussex)
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Maycroft Place, Stone Cross, TN20 6EW

Start date

On request

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Teachers and trainers (1)

Dr Peter Lowe Novobio

Dr Peter Lowe Novobio

Head of Biological Technology at Roche Discovery Welwyn

Dr Peter Lowe, Novobio. Peter Lowe’s training and postdoctoral research was in protein biochemistry in the UK and USA. At Celltech, he was involved in the early application of recombinant DNA technology to biopharmaceutical proteins. Later, becoming Head of Biological Technology at Roche Discovery Welwyn, he was responsible for High-throughput screening. ...

Course programme

Your compound's quality and value is often expressed in biological terms such as:

compound potency, selectivity, ADMET, mode of action and efficacy. These attributes cover a remarkably wide range of biological technology
In a typical drug discovery programme Medicinal Chemists are exposed to a flood of biological data in their day-to-day work. Hence, in order for you to assess the quality and value of your own compounds, it is important to add continually an appreciation of Biology to your range of skills.

This course is for Medicinal Chemists and Project Managers who wish to gain an improved feel for drug discovery biology. The biological world is immense and therefore the course drills down to provide an overview of only those key areas of biology relevant to the
Medicinal Chemist in a drug discovery environment. The order in which various biological attributes are generated in the total drug discovery process is also provided in the course.

At the end of the course the Medicinal Chemist should be better positioned to analyse and interpret the biological data used to evaluate their compounds.

Outline

Overview of fundamental biology relevant to Medicinal Chemists

Biology of the major drug target classes:

• their structure, function and relative target tractability.

Key biological tools of the trade/ interpretation of the data they generate:

• in vitro compound potency and selectivity: bioassay formats and design, enzyme inhibition, receptor binding modulation, low-throughput screening, high-throughput screening, bioassay automation, micro-scale bioassays, bioassay in cell culture, high content screening.
• biostructural (X-ray) analysis of the compound-target protein complex
• Global Technologies: genomics, structural genomics, proteomics, chemogeomics
• methods for in vitro ADMET assays: P450 inhibition, metabolic stability, protein binding,
permeability, glucuronidation, cytotoxicity assays, hERG assay

Animal models of disease:

• selected key animal models, their application and value.

Biological data handling:

• methods for quality assessment and interpretation.

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Essential Biology for Medicinal Chemists

Price on request

The best Chemistry courses

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