Biomaterials-tissue interactions
Master
In Maynard (USA)
Description
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Type
Master
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Location
Maynard (USA)
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Start date
Different dates available
This course covers the principles of materials science and cell biology underlying the design of medical implants, artificial organs, and matrices for tissue engineering. Methods for biomaterials surface characterization and analysis of protein adsorption on biomaterials. Molecular and cellular interactions with biomaterials are analyzed in terms of unit cell processes, such as matrix synthesis, degradation, and contraction. Mechanisms underlying wound healing and tissue remodeling following implantation in various organs. Tissue and organ regeneration. Design of implants and prostheses based on control of biomaterials-tissue interactions. Comparative analysis of intact, biodegradable, and bioreplaceable implants by reference to case studies. Criteria for restoration of physiological function for tissues and organs.
Facilities
Location
Start date
Start date
Reviews
Subjects
- Tissue Engineering
- Engineering
- Materials
- Design
- Biology
Course programme
Lectures: 2 sessions / week, 1.5 hours / session
The goal of this subject is to teach the physical and biological principles that serve as the scientific basis for understanding the interactions of biological molecules and cells with biomaterials employed for the fabrication of permanent implantable prostheses and as matrices for tissue engineering.
Chemistry GIR (3.091, 5.111, or 5.112)
Thermal-Fluids Engineering I (2.005) or Thermodynamics and Kinetics (5.60)
Biology GIR (7.012, 7.013, or 7.014)
Readings from the literature will be assigned for many classes. Selected readings will also be assigned from the course textbook:
Yannas, I. V. Tissue and Organ Regeneration in Adults. New York, NY: Springer, 2001. ISBN: 9780387952147.
Most of the homework questions are quiz questions from prior years. Homework sets will be graded on a scale of 0-3.
The final grade will be based principally on 3 quizzes. Performance on the homework sets and class participation may also be taken into consideration, particularly for borderline grades.
Tissue structures and unit cell processes
Integrins and adhesion proteins
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Biomaterials-tissue interactions