Biomolecular kinetics and cellular dynamics
Master
In Maynard (USA)
Description
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Type
Master
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Location
Maynard (USA)
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Start date
Different dates available
This subject deals primarily with kinetic and equilibrium mathematical models of biomolecular interactions, as well as the application of these quantitative analyses to biological problems across a wide range of levels of organization, from individual molecular interactions to populations of cells.
Facilities
Location
Start date
Start date
Reviews
Subjects
- Engineering
Course programme
Lectures: 2 sessions / week, 1.5 hours / session
In this course you will learn to construct kinetic and equilibrium mathematical models of biomolecular interactions, and apply these quantitative analyses to biological problems across a wide range of levels of organization, from individual molecular interactions to populations of cells.
Lauffenburger, Douglas A., and J. Jennifer Linderman. Receptors: Models for Binding, Trafficking, and Signaling. New York, NY: Oxford University Press, 1995. ISBN: 9780195106633.
Hammes, Gordon G. Thermodynamics and Kinetics for the Biological Sciences. Hoboken, NJ: John Wiley and Sons, 2000. ISBN: 9780471374916.
Creighton, Thomas E. Proteins: Structures and Molecular Properties. 2nd ed. New York, NY: W.H. Freeman and Company, 1993. ISBN: 9780716723172.
Bailey, James, and David F. Ollis. Biochemical Engineering Fundamentals. 2nd ed. New York, NY: McGraw Hill Higher Education, 1986. ISBN: 9780070032125.
Steinfeld, Jeffrey I., J. S. Francisco, and W. L. Hase. Chemical Kinetics and Dynamics. 2nd ed. E. Upper Saddle River, NJ: Prentice Hall PTR, 1998. ISBN: 9780137371235.
Cantor, Charles R., and Paul R. Schimmel. Biophysical Chemistry. New York, NY: W.H. Freeman, 1980. ISBN: 9780716711889, ISBN: 9780716711902, and ISBN: 9780716711926.
Blanch, Harvey W., and D. S. Clark, eds. Biochemical Engineering. Boca Raton, FL: CRC, 1997. ISBN: 9780824700997.
Shargel, Leon, et al. Applied Biopharmaceutics and Pharmacokinetics. New York, NY: McGraw-Hill Professional Publishing, 2004. ISBN: 9780071375504.
Carberry, James J. Chemical and Catalytic Reaction Engineering. New York, NY: McGraw-Hill, 1976. ISBN: 9780070097902.
Strogatz, Steven H. Nonlinear Dynamics and Chaos: With Applications to Physics, Biology, Chemistry, and Engineering. Cambridge, MA: Perseus Publishing, 2001. ISBN: 9780738204536.
There will be a total of twelve assignments. Initial homework assignments will focus on mathematical modeling and concepts covered in class, including some work in MATLAB®. Later assignments will consist of more involved work in MATLAB®, implementing models described in assigned papers from the literature.
Grading Scale for Model Implementations (PDF)
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Biomolecular kinetics and cellular dynamics