Molecular biology for the auditory system
Master
In Maynard (USA)
Description
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Type
Master
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Location
Maynard (USA)
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Start date
Different dates available
An introductory course in the molecular biology of the auditory system. First half focuses on human genetics and molecular biology, covering fundamentals of pedigree analysis, linkage analysis, molecular cloning, and gene analysis as well as ethical/legal issues, all in the context of an auditory disorder. Second half emphasizes molecular approaches to function and dysfunction of the cochlea, and is based on readings and discussion of research literature.
Facilities
Location
Start date
Start date
Reviews
Subjects
- Molecular Biology
- Genetics
- Biology
Course programme
Lectures / Labs: 2 sessions / week, 1.5 hours / session
During the semester we will cover the exciting advances in the genetics and molecular biology of the inner ear. For the non-molecular biologists in the class, we will begin with a few lectures on basic molecular biology and genetics, covering both theory and techniques. We will also include an inner ear physiology review. We will study techniques for identifying "deafness genes" as well as genes and proteins recently identified as being critical for proper inner ear function. We will cover topics relating to inner ear development and hair cell regeneration. Additional lectures will explore recent advances in the field, studying such topics as syndromic and nonsyndromic hearing loss and the molecules that are responsible for hearing loss, such as connexins, myosins, transcription factors, extracellular matrix proteins and ion channels. We will also discuss techniques, such as the use of embryonic stem cells, used to further investigations into inner ear function. The lead faculty will deliver approximately half of the lectures, with the remaining lectures given by inner ear/deafness research experts from the Boston area.
The course this year will include a hands-on laboratory component, in which each student will perform basic molecular biology techniques for gene discovery. The students' research projects will be presented in class at the end of the semester. In addition, each student will present for discussion papers that cover in depth some of the topics discussed in class.
The course this year will include a hands-on laboratory component, in which each student will perform basic molecular biology techniques for gene discovery. Each student will have his/her own mini-research project. Results of students' research projects will be presented in class at the end of the semester.
Twice during the semester, each student will present for discussion papers that cover in depth the topics discussed in class. These presentations are designed to familiarize students with techniques and strategies used by investigators to study the molecular biology of the auditory system.
Grades will be assigned based upon student participation in class, student presentations of lab work and journal articles, and a final exam.
For coverage of basic molecular biology, we recommend Molecular Biology of the Cell by Bruce Alberts et al., 2002, Garland Science.
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Molecular biology for the auditory system