At the MRC PPU, as well as the possibility of a PhD in one particular lab, we offer the possibility of two 4.5-month rotations in labs of their choice. A range of other projects from MRC PPU scientists are advertised on this website. Rotations provide valuable experience and help with deciding on the choice of PhD project and research group.
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Dundee
(Dundee City)
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Fulton Building, DD1 4HN
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Different dates availableEnrolment now open
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This centre's achievements
2019
All courses are up to date
The average rating is higher than 3.7
More than 50 reviews in the last 12 months
This centre has featured on Emagister for 14 years
Subjects
Microscopy
Fluorescence
Biology
Molecular Biology
Cell
Technologies
Protein chemistry
Chemistry
Biochemistry
Spectrometry
Course programme
Wnt signalling plays a fundamental role during development and in adult tissue homeostasis. Aberrant functions of many Wnt components are associated with many human diseases, including cancer and skin disorders. The Sapkota lab recently discovered PAWS1 (a.k.a. FAM83G) as a key regulator of Wnt signalling. Furthermore, PAWS1 mutations cause Palmoplantar Hyperkeratosis, which is characterised by thickening of footpads, epidermal hyperplasia and abnormal hair growth. We have found that the association of PAWS1 with a Ser/Thr protein kinase Casein Kinase 1 alpha (CK1) is critical for the regulation of Wnt signalling. We hypothesize that PAWS1 directs CK1 to specific subcellular compartment and substrates to control Wnt signalling. This project aims to identify key PAWS1-dependent, CK1 substrates in Wnt signalling and dissect the molecular mechanisms by which the phosphorylation of these substrates controls Wnt signalling responses in cells. The project will offer outstanding training opportunities in cutting-edge technologies in cell and molecular biology, protein chemistry, and biochemistry, including CRISPR/Cas9 genome editing, quantitative phospho-proteomics, mass-spectrometry, and fluorescence microscopy. We collaborate with leading pharmaceutical companies so that any exciting discoveries and innovative ideas can be expedited into potential drug discovery programmes.
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Define the molecular mechanisms by which PAWS1 controls Wnt signalling
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