At the MRC PPU, as well as the possibility of a PhD in one particular lab, we offer the possibility of two 4.5-month rotations in labs of their choice. A range of other projects from MRC PPU scientists are advertised on this website. Rotations provide valuable experience and help with deciding on the choice of PhD project and research group.
Facilities
Location
Start date
Dundee
(Dundee City)
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Fulton Building, DD1 4HN
Start date
Different dates availableEnrolment now open
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This centre's achievements
2019
All courses are up to date
The average rating is higher than 3.7
More than 50 reviews in the last 12 months
This centre has featured on Emagister for 13 years
Subjects
Autophagy
Mechanism
Molecular
Molecular mechanism
Potentially damaging
Mitochondria
Diseases
Dysregulated
Therapies
Cell Metabolism
Course programme
The Ganley lab is interested in unravelling the molecular mechanism of autophagy (which literally translates from the Greek meaning to eat oneself). Autophagy functions to clear the cell of potentially damaging agents, such as protein aggregates or faulty mitochondria, as well as acting as a recycling station to supply essential building blocks during periods of starvation. The autophagy field is a rapidly growing area of research, one of the reasons being that it is dysregulated in many diseases and therefore its modulation could lead to novel therapies. To enable this, we first need to understand the machinery involved. A project is available to decipher the signals that lead to the specific autophagy of mitochondria (termed mitophagy), a process that has been linked to Parkinson’s disease and cancer. Following up on recently published work (see McWilliams et al., 2018, Cell Metabolism), the project will utilise state-of-the-art microscopy, protein biochemistry and high-throughput screening to identify phosphorylation and ubiquitylation events involved in capturing mitochondria for degradation.
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