There is overwhelming evidence that inflammation contributes to the development of cardiovascular disease (CVD)but counterbalancing this is evidence from meta-analysis of randomised control trials that many existing anti-inflammatory drugs, such as COX2 inhibitors and anti-TNF drugs, tend if anything to exacerbate risk of CVD. If inflammation is to be targeted successfully in CVD, new paradigms of drug action and new approaches to patient selection need to be generated. Our recent work has been on metformin, which in observational studies also reduces risk of CVD.
Facilities
Location
Start date
Dundee
(Dundee City)
See map
Fulton Building, DD1 4HN
Start date
Different dates availableEnrolment now open
Questions & Answers
Add your question
Our advisors and other users will be able to reply to you
We are verifying your question adjusts to our publishing rules. According to your answers, we noticed you might not be elegible to enroll into this course, possibly because of: qualification requirements, location or others. It is important you consult this with the Centre.
Thank you!
We are reviewing your question. We will publish it shortly.
Or do you prefer the center to contact you?
Reviews
Have you taken this course? Share your opinion
This centre's achievements
2019
All courses are up to date
The average rating is higher than 3.7
More than 50 reviews in the last 12 months
This centre has featured on Emagister for 14 years
Subjects
Risk
IT risk
Inflammatory
Immunometabolic
Mechanisms
Homeostasis
Drugs
Diabetic
Human Disease
Disease
Molecular
Course programme
Our work in this area has established that anti-inflammatory effects of metformin are exerted irrespective of diabetes status[1, 2], through poorly understood ‘immunometabolic’ mechanisms that are different from existing anti-inflammatory drugs and which we have recently found are accompanied by changes in amino acid homeostasis.Better understanding of these effects is likely to have a high-impact, by supporting better stratification and targeting of repurposing trials of metformin in non-diabetic CVD [1].To ensure relevance to human disease,it is desirable to extend our studies from rodent-derived cells to include human-derived cells. To do this, the student will identify and then use a suitable human cell model to investigate the relationship between amino acid metabolism and immune effects of the drug. This will include evaluation of immortalised cell lines, such as U-937, HL-60 or THP1, to identify combinations of cells/stimuli suitable for further study.Combination of data from human cell studies with (mouse) knockout cells from our network of collaborators and with biomarkers in human plasma stored from previous clinical trials,as well as exploitation of state-of-the-art patient databases, provides the student with an outstanding platform to establish high-impact translational cross-validation of clinical observations with cell/molecular findings,as demonstrated in our highly interdisciplinary recent work [1, 2]
See related categories
Postgraduate Degrees in Scotland
Other Health Postgraduate Degrees
Distance learning Other Health Postgraduate Degrees
Other Health Postgraduate Degrees in Scotland
University of Dundee Postgraduate Degrees
Interdisciplinary investigation of the role of amino acids in immunometabolic responses to metformin in humans
Add similar courses and compare them to help you choose.
{title}
{rating}
{centerName}
{price}
{price}{priceBeforeDiscount}{taxCaption}
{options}
Training by subject
Postgraduate Degrees of Business and Management Postgraduate Degrees of Design and Media Postgraduate Degrees of Finance Postgraduate Degrees of Health Postgraduate Degrees of Humanities, Social Science, Education Postgraduate Degrees of Industry and Science Postgraduate Degrees of IT, Computing, Telecommunications Postgraduate Degrees of Languages Postgraduate Degrees of Law and Defence Postgraduate Degrees of Sales and Marketing Postgraduate Degrees of Sports and Leisure Postgraduate Degrees of Tourism and Hospitality