Health Degrees in the Scotland

...interplay between phosphorylation and ubiquitylation in many signalling pathways, emphasizing the importance of studying both kinds of modification in an integrated fashion... Learn about: DNA repair, DNA Replication...

...our understanding of neurodegenerative diseases. We recently discovered a new family of DUBs that regulate protein degradation signals. The available projects... Learn about: Structural Biology, Biology Science...

...of PhD project and research group. Increasing evidence shows that alterations and mutations in the UPS give rise to various human diseases, such as cancer... Learn about: Human Diseases...

...replace these models is currently available and secondly because they both constitute vitally important pre-clinical evidence with published acceptance... Learn about: Medical training, Physical prototype, 3d training...

...However, intensive treatment with insulin or sulphonylureas is associated with an increased risk of hypoglycaemia (low blood glucose), the occurrence... Learn about: Blood glucose, Health Care, Diabetes Nutrition...

...Resonance guided Focused Ultrasound Surgery (MRgFUS). Integrating Focused ultrasound (FUS) and MRI as a thermal ablation therapy delivery system allows to localize... Learn about: Clinical routine...

...on how this is included in an already busy curriculum (2). In the UK, there has been a variety of different initiatives and awards to support E&I development... Learn about: Clinical Statistics, Developing Clinical, Clinical Governance...

...the impracticality of seeking consent of patients, challenges of de-identification of image data, absence of non-proprietary software for efficient handling... Learn about: Research data, Medical training, Data Management...

...catalogue of genetic abnormalities in human cancer, and in some tumour types provided classifications useful for clinical decision making. However... Learn about: Clinical phenotype, Clinical decision, Genetic abnormalities...

...and thus improving our understanding of the clinically relevant GSK3 targets in these diseases should provide opportunities for novel interventions... Learn about: Chronic lymphocytic, Human CLL...

...Diabetes and chronic heart failure (CHF) often coexist such that each condition may affect the other in terms of causation and outcome. This bidirectional...

...The candidate will use in vivo models to ask whether the organisms response to repeated hypoglycaemia meets the characteristics of a habituated response... Learn about: Diabetes Clinical Care, Diabetes Care, Severe hypoglycaemia...

...We will use this preliminary data to present to both industrial and non-industrial funding sources to facilitate translation of these potential compounds to the clinic... Learn about: Drug Discovery, Phenotypic Screening...

...The anti-inflammatory drug sulfasalazine, which is used in rheumatoid arthritis and inflammatory bowel disease, was reported earlier to suppress HbA1c...

...is likely to have a high-impact, by supporting better stratification and targeting of repurposing trials of metformin in non-diabetic CVD [1].To ensure... Learn about: IT risk, Human Disease...

...required to analyse the data (Thanasis). We aim to keep this process iterative as we plan to use this project as a baseline for a longer-term fruitful collaboration... Learn about: Physical computing, Physical Chemistry, Physical Intervention...

...and integrated proteogenomic analyses to further characterise this classic subtype in SCCs across multiple anatomical sites. This proposal will investigate... Learn about: Human solid...

...Squamous cell carcinomas across multiple sites (lung, head and neck, skin, oesophagus) represent the most frequent human malignancies and are a major cause... Learn about: IT risk...

...The PhD project will be based in either Dundee or Edinburgh, but will be highly collaborative with significant interaction with the co-supervisor at the partner University...

...The project will involve cell culture, transfection, quantitative real-time PCR, immunoblotting, and immunofluorescence imaging...