Health Degrees in the Scotland

...interplay between phosphorylation and ubiquitylation in many signalling pathways, emphasizing the importance of studying both kinds of modification in an integrated fashion... Learn about: DNA repair, DNA Replication...

...and cell biology techniques to dissect how MINDY DUBs control protein degradation. Specifically, you will address how protein degradation is regulated... Learn about: Biology Science, Structural Biology...

...At the MRC PPU, as well as the possibility of a PhD in one particular lab, we offer the possibility of two 4.5-month rotations in labs of their choice... Learn about: Human Diseases...

...The proposed project aims to reduce, refine and replace live animal experiments according to the 3R principle (Replacement-Reduction-Refinement)... Learn about: Virtual CAD, Physical prototype, 3d training...

...that aims to study the consequences of recurrent hypoglycaemia in Type 1 and 2 diabetes. This PhD will focus on examining the impact of recurrent hypoglycaemia... Learn about: Diabetes Care, Blood glucose, Health Care...

...This project thus involves design, development and testing of a MR compatible biophotonic probe and combing it with the MRI image guidance. This multimodality... Learn about: Clinical routine...

...on how this is included in an already busy curriculum (2). In the UK, there has been a variety of different initiatives and awards to support E&I development... Learn about: Clinical Service, Clinical coding, Clinical Statistic...

...development of novel computer vision methods for biomarker extraction, validation of novel algorithms and machine learning approaches and discovery... Learn about: Medical training, Research data, Data Management...

...we have combined whole genome sequencing and mass spectrometry based quantitative proteomics to perform an integrated proteogenomic analysis of oesophageal adenocarcinoma... Learn about: Clinical decision, Genetic abnormalities, Clinical phenotype...

...In collaboration with Dr Jeffrey Huang, Biomarker Service, we will use quantitative proteomics (10plex-ITRAQ) to compare the expression level of the cellular... Learn about: Chronic lymphocytic, Human CLL...

...reduction of the ECM components has the potential of improving insulin sensitivity in the heart of insulin resistant mouse models. This project aims...

...to working at the interface between human and bench translational research... Learn about: Diabetes Clinical Care, Diabetes Care, Diabetes Nutrition...

...invasive and not without risk. Despite this, year-on-year, ART is increasingly utilized worldwide. There is clearly an unmet need for the development... Learn about: Drug Discovery, Phenotypic Screening...

...make high-impact findings relevant to clinical practice,through cross-validation of clinical and cell/molecular insights. To follow up the preliminary...

...of data from human cell studies with (mouse) knockout cells from our network of collaborators and with biomarkers in human plasma stored from previous... Learn about: IT risk, Human Disease...

...and will be assisting in posing key questions that are useful from a practitioner’s perspective, and also in interpreting findings. Physical visits... Learn about: Physical computing, Physical Intervention, Clinical PhD...

...head and neck and oesophageal SCCs, that is characterised by frequent NRF2 and KEAP1 mutations. We aim to use functional investigations of the NRF2 pathway... Learn about: Human solid...

...of cancer mortality with limited therapeutic options for advanced disease. Immunotherapies such as immune checkpoint inhibitors (ICi) have changed... Learn about: IT risk...

...trials to enhance our understanding of the mechanisms of Parkinson’s and exploit this knowledge to develop and evaluate novel therapies in the clinic...

...which have a characteristic chemical signature: the ability to react with sulfhydryl groups. Using the human osteosarcoma cell line U2OS, we recently found that two Nrf2 activators...