Design of Experiments for Bioprocess Optimisation (MBI® Training, Bioprocess Industries)

Teaching is in small classes, with an emphasis on interactive problem solving and case studies.

Each day will cover the following topics:

• The principles and benefits of DoE approaches, compared to one-factor-at-a-time (OFAT) investigations
• Experimental design techniques and interactive demonstration of DoE software packages (Design Expert 8 and ProSim)
• Case studies: analytical method validation (conventional vs DoE approach)
• Industrial analytical method validation using DoE

• Screening and optimisation of microbial fermentations
• Case study: fermentation process screening
• Case study: fermentation process optimisation and scaleup
• Protein refolding, stabilisation and formulation: structural and environmental parameters that impact on maintenance and stabilisation of protein structure and activity

• Case study: primary product recovery by microfiltration
• The application of factorial design in high throughput scale-down bioprocess development: examples in fermentation and cell culture
• Experimental planning and DoE for chromatography
• Discussion forum

A social networking event will be held for delegates and speakers.