Genetics

Courses

GENE 555a / CB&B 555a / CPSC 553a, Machine Learning for Biology  Smita Krishnaswamy

This course introduces biology as a systems and data science through open computational problems in biology, the types of high-throughput data that are being produced by modern biological technologies, and computational approaches that may be used to tackle such problems. We cover applications of machine-learning methods in the analysis of high-throughput biological data, especially focusing on genomic and proteomic data, including denoising data; nonlinear dimensionality reduction for visualization and progression analysis; unsupervised clustering; and information theoretic analysis of gene regulatory and signaling networks. Students’ grades are based on programming assignments, a midterm, a paper presentation, and a final project.
TTh 11:35am-12:50pm

GENE 625a / MB&B 625a / MCDB 625a, Basic Concepts of Genetic Analysis  Jun Lu

The universal principles of genetic analysis in eukaryotes are discussed in lectures. Students also read a small selection of primary papers illustrating the very best of genetic analysis and dissect them in detail in the discussion sections. While other Yale graduate molecular genetics courses emphasize molecular biology, this course focuses on the concepts and logic underlying modern genetic analysis.
MW 11:35am-12:50pm

GENE 655a / CBIO 655a, Stem Cells: Biology and Application  In-Hyun Park

This course is designed for first-year or second-year students to learn the fundamentals of stem cell biology and to gain familiarity with current research in the field. The course is presented in a lecture and discussion format based on primary literature. Topics include stem cell concepts, methodologies for stem cell research, embryonic stem cells, adult stem cells, cloning and stem cell reprogramming, and clinical applications of stem cell research. Prerequisites: undergraduate-level cell biology, molecular biology, and genetics.
Th 1:30pm-3pm

GENE 675a and GENE 676b, Graduate Student Seminar: Critical Analysis and Presentation of Scientific Literature  Valentina Greco

Students gain experience in preparing and delivering seminars and in discussing presentations by other students. A variety of topics in molecular, cellular, developmental, and population genetics are covered. Required of all second-year students in Genetics. Graded Satisfactory/Unsatisfactory.
W 2pm-3:30pm

GENE 743b / MB&B 743b / MCDB 743b, Advanced Eukaryotic Molecular Biology  Mark Hochstrasser and Wendy Gilbert

Selected topics in transcriptional control, regulation of chromatin structure, mRNA processing, mRNA stability, RNA interference, translation, protein degradation, DNA replication, DNA repair, site-specific DNA recombination, somatic hypermutation. Prerequisite: biochemistry or permission of the instructor.
TTh 11:35am-12:50pm

GENE 749a / MB&B 749a, Medical Impact of Basic Science  Joan Steitz, Peter Moore, Scott Strobel, I. George Miller, David Schatz, Daniel DiMaio, Sandy Chang, Karla Neugebauer, and Wendy Gilbert

Consideration of examples of recent discoveries in basic science that have elucidated the molecular origins of disease or that have suggested new therapies for disease. Emphasis is placed on the fundamental principles on which these advances rely. Reading is from the primary scientific and medical literature, with emphasis on developing the ability to read this literature critically. Aimed primarily at undergraduates. May not be taken by MB&B B.S./MS. students for graduate course credit. Prerequisite: biochemistry or permission of the instructor.
MW 1pm-2:15pm

GENE 760b, Genomic Methods for Genetic Analysis  James Noonan

Introduction to the analysis and interpretation of genomic datasets. The focus is on next-generation sequencing (NGS) applications including RNA-seq, ChIP-seq, and exome and whole genome sequencing. By the end of the course, each student will be able to process and analyze large-scale NGS datasets and interpret the results. This course is intended only for graduate students who are interested in applying genomic approaches in their thesis research. At a minimum, students must have basic familiarity with working in a UNIX/Linux computing environment. Prior experience with shell scripting or a scripting language such as Perl, Python, or Ruby is strongly recommended. Interested students must contact the instructor early in the fall term to discuss their prior experience and expectations for the course. Enrollment limited to twenty. Prerequisite: permission of the instructor.
W 9:30am-10:45am, M 10:30am-11:45am, Th 12pm-2pm

GENE 777b / MCDB 677b, Mechanisms of Development  Zhaoxia Sun

An advanced course on mechanisms of animal development focusing on the genetic specification of cell organization and identity during embryogenesis and somatic differentiation. The use of evolutionarily conserved signaling pathways to carry out developmental decisions in a range of animals is highlighted. Course work includes student participation in critical analysis of primary literature and a research proposal term paper.
W 1:30pm-3:20pm

GENE 900a / CBIO 900a / MCDB 900a, Research Skills and Ethics I  Valerie Horsley

This course consists of a weekly seminar that covers ethics, writing, and research methods in cellular and molecular biology as well as student presentations (“rotation talks”) of work completed in the first and second laboratory rotations.
M 4pm-5:30pm

GENE 901b / CBIO 901b / MCDB 901b, Research Skills and Ethics II  Joerg Bewersdorf

This course consists of a weekly seminar that covers ethics, writing, and research methods in cellular and molecular biology as well as student presentations (“rotation talks”) of work completed in the third laboratory rotation.
Th 4pm-5:30pm

GENE 911a / CBIO 911a / MCDB 911a, First Laboratory Rotation  Valerie Horsley

First laboratory rotation for Molecular Cell Biology, Genetics, and Development track students.
HTBA

GENE 912a / CBIO 912a / MCDB 912a, Second Laboratory Rotation  Valerie Horsley

Second laboratory rotation for Molecular Cell Biology, Genetics, and Development track students.
HTBA

GENE 913b / CBIO 913b / MCDB 913b, Third Laboratory Rotation  Valerie Horsley

Third laboratory rotation for Molecular Cell Biology, Genetics, and Development track students.
HTBA