Health Postgraduate Degrees in the Scotland

...is regulated upon proteotoxic stresses in a phosphorylation-dependent manner (Rousseau and Bertolotti, 2016, Nature). The new project will focus on... Learn about: Human Diseases...

...motion and complex vessels for pulsatile blood flow and bleeding simulation. For this, the complexity of surrounding tissues and vascular structures... Learn about: Medical imaging, Medical training, Physical prototype...

...However, intensive treatment with insulin or sulphonylureas is associated with an increased risk of hypoglycaemia (low blood glucose), the occurrence... Learn about: Blood glucose, Diabetes Care, Diabetes Nutrition...

...a novel MR compatible optical fibre based biophotonic probe for “in situ” pathologic diagnosis (optical Biopsy) of a targeted tumor suspicious lesion... Learn about: Clinical routine...

...be based on experiential approaches to learning is gaining ground. However, there is both little discussion in the literature on what form experiential... Learn about: Clinical Service, Developing Clinical, Clinical Teaching...

...which meets the requirements of data governance and also researchers who wish to utilise the images in secure environments. The project will build... Learn about: Data Management, Medical training, Research data...

...potential translational impact as targets e.g. repurposing of existing targets and agents to application in oesophageal cancer precision medicine strategies... Learn about: Clinical decision, Clinical phenotype, Genetic abnormalities...

...with more than 20 GSK3 substrates targeted for destruction following phosphorylation . We have a BBSRC funding application pending a decision... Learn about: Chronic lymphocytic, Human CLL...

...show that cardiac insulin resistance may be associated with increased deposition of ECM components, such as collagen III and collagen IV. Importantly...

...that the primary driver towards the development of IAH is prior exposure to repeated episodes of hypoglycaemia. However, we still do not know why repeated... Learn about: Diabetes Nutrition, Diabetes Care, Diabetes Clinical Care...

...2018). We (Andrews/Barratt) have developed a high throughput phenotypic screening platform for measuring both human sperm motility and acrosome reaction... Learn about: Drug Discovery, Phenotypic Screening...

...This will include the effect of the drug on haemolysis, inflammatory and metabolic signalling, insulin sensitivity, glucose uptake, hepatic glucose production...

...of data from human cell studies with (mouse) knockout cells from our network of collaborators and with biomarkers in human plasma stored from previous... Learn about: Human Disease, IT risk...

...Gordon) to develop a solid background in this domain and keep on coming with interesting new clinical questions, and also to master the analytical techniques... Learn about: Physical computing, Physical Intervention, Clinical PhD...

...head and neck and oesophageal SCCs, that is characterised by frequent NRF2 and KEAP1 mutations. We aim to use functional investigations of the NRF2 pathway... Learn about: Human solid...

...have changed the therapeutic landscape for many cancers, but the strong association between immunosuppression/immune evasion and poor SCC outcomes implies... Learn about: IT risk...

...The PhD project will be based in either Dundee or Edinburgh, but will be highly collaborative with significant interaction with the co-supervisor at the partner University...

...phenethyl isothiocyanate and bis(2-hydroxybenzylidene)acetone, inhibit mTOR. The aim of this project is to gain insights into the mechanism by which sulfhydryl-reactive...

...Nrf2 and the NFkappaB/TNFalpha axis, as a mechanism responsible for the switch from steatosis (viewed as successful adaptation) to steato-hepatitis...

...The UK Biobank cohort released the genetic information relating to 500,000 participants in September 2017. The rich phenotypic information also available...