University of Dundee courses

...which meets the requirements of data governance and also researchers who wish to utilise the images in secure environments. The project will build... Learn about: Medical training, Data Management, Research data...

...discovery work developed as a core part of this project. Overall aim is to develop a methylation biomarker panel as a strategic assay for use in an NHS diagnostic setting... Learn about: NHS health, NHS Training...

...and how this affects the cancer cell phenotype and ultimately the clinical phenotype. In collaboration with the Scottish genomes partnership... Learn about: Genetic abnormalities, Clinical phenotype, Clinical decision...

...and suggested a role for oxidative stress in the disease process. Pathological changes in Nrf2, Mcl-1 and Wnt/β-catenin signalling have been recognised in both CLL and... Learn about: Chronic lymphocytic, Human CLL...

...of the ECM in cardiac insulin resistance and CHF and ECM may well become a target for therapy in diabetic cardiovascular disease. This research project...

...Confirmation of this will provide the first clear explanation as to why IAH develops in people with T1 and long-duration T2D who are exposed to multiple episodes of hypoglycaemia... Learn about: Diabetes Clinical Care, Diabetes Care, Diabetes Nutrition...

...Infertility is a significant global problem affecting ~1 in 7, or ~80 million couples (Barratt et al., 2017). Although the causes of infertility are heterogeneous... Learn about: Drug Discovery, Phenotypic Screening...

...in many areas of medicine for guiding clinical practice and research. However, despite considerable interest in identifying brain biomarkers... Learn about: Chemotherapy CIPN...

...as well as changes in prescription of oral anti-hyperglycaemic medications or insulin. This element will comprise one third of the studentship...

...relevance to human disease,it is desirable to extend our studies from rodent-derived cells to include human-derived cells. To do this, the student... Learn about: Human Disease, IT risk...

...This will be complemented with cell biology in human cells (using CRISPR/Cas9 engineering and advanced microscopy techniques) to investigate their functional... Learn about: Human cells, Cell Biology...

...that the whole leptin molecule is not required for bioactivity, as a leptin fragment (leptin amino acids 116-130) mirrors the cognitive enhancing and neuroprotective...

...with the ultimate goal of providing better longitudinal quantitative insights into PD symptom progression. How is the project collaborative?... Learn about: Physical computing, Clinical PhD, Physical Education...

...This will include the study of gluconeogenesis, insulin uptake, insulin sensitivity, and hepatic glucose output. This model will also be used to comapre... Learn about: Nature Genetics...

...head and neck and oesophageal SCCs, that is characterised by frequent NRF2 and KEAP1 mutations. We aim to use functional investigations of the NRF2 pathway... Learn about: Human solid...

...paraffin-embedded (FFPE) pathology blocks. Pilot data from this group has shown great success in successfully stratifying cancer transcriptomes from cutaneous... Learn about: IT risk...

...a protein aggregation assay, RT-QuIC, which detects aggregated α-synuclein in cerebrospinal fluid (CSF).5 The aim of this project would be to use these...

...programs of electrical stimulation can reverse insulin resistance and steato-hepatitis resolving NASH in patients. The project will measure a range...

...of primary human tumour material. These studies will identify novel mediators of TGF signalling, biomarkers for the use of TGF targeted therapeutics...

...Second, we will determine whether inhibition of mTOR by these compounds is a general phenomenon by using a number of different cancer cell lines (neuroblastoma...