University of Dundee courses

...are extremely useful for research into areas including: early/preclinical diagnosis, disease progression, validation of treatment methods, development... Learn about: Data Management, Medical training, Research data...

...whilst validating cancer-specific methylation will increase our understanding of the mechanisms driving metastasis in melanoma. Previous work by this group... Learn about: NHS Training, NHS health...

...potential translational impact as targets e.g. repurposing of existing targets and agents to application in oesophageal cancer precision medicine strategies... Learn about: Genetic abnormalities, Clinical decision, Clinical phenotype...

...and suggested a role for oxidative stress in the disease process. Pathological changes in Nrf2, Mcl-1 and Wnt/β-catenin signalling have been recognised in both CLL and... Learn about: Chronic lymphocytic, Human CLL...

...test the hypothesis that reduction of heart ECM protein could rescue cardiac insulin resistance, which has the potential of improving cardiac function...

...Confirmation of this will provide the first clear explanation as to why IAH develops in people with T1 and long-duration T2D who are exposed to multiple episodes of hypoglycaemia... Learn about: Diabetes Clinical Care, Diabetes Nutrition, Diabetes Care...

...invasive and not without risk. Despite this, year-on-year, ART is increasingly utilized worldwide. There is clearly an unmet need for the development... Learn about: Phenotypic Screening, Drug Discovery...

...Acute pain is intrinsically unpleasant and aversive but is useful as it has survival benefit. However, many people suffer from chronic treatment-resistant... Learn about: Chemotherapy CIPN...

...and insulin secretion. In addition, investigation of analogues of the drug will enable the pharmacophore of any effects to be established, as sulfasalazine...

...Our recent work has been on metformin, which in observational studies also reduces risk of CVD. Our work in this area has established that anti-inflammatory... Learn about: Human Disease, IT risk...

...extract system and mass spectrometry to quantify these dynamics on a global scale... Learn about: Cell Biology, Human cells...

...may be beneficial in AD. Indeed, our recent studies support this as we have identified not only a cognitive enhancing role for leptin (1), but treatment...

...Ultimately, this may lead to a fragmented picture of daily aspects in understanding the extent of PD symptoms, which leads to suboptimal treatment... Learn about: Physical computing, Physical Intervention, Physical Chemistry...

...clarify the mechanisms linking ATM, nutrient sensing and metformin response... Learn about: Nature Genetics...

...head and neck and oesophageal SCCs, that is characterised by frequent NRF2 and KEAP1 mutations. We aim to use functional investigations of the NRF2 pathway... Learn about: Human solid...

...that early use of such agents will be essential necessitating robust identification of ‘high-risk’ SCC at diagnosis for stratification to receive adjuvant strategies... Learn about: IT risk...

...by increasing LRRK2 kinase activity. The penetrance of LRRK2 mutations is highly variable and at present there is no means of predicting if and when non-manifesting...

...Many patients can’t or won’t achieve this with conventional means. The pathogenic process of the disease is insulin resistance, and this can be reversed...

...tumour progression will be interrogated for biological activity using real-time imaging, cell biological and biochemical assays coupled with interrogation...

...Second, we will determine whether inhibition of mTOR by these compounds is a general phenomenon by using a number of different cancer cell lines (neuroblastoma...