University of Dundee courses

...which meets the requirements of data governance and also researchers who wish to utilise the images in secure environments. The project will build... Learn about: Research data, Medical training, Data Management...

...in a 384-well format allowing simultaneous testing for cancer-associated methylation at multiple CpG islands in multiple genes in multiple samples... Learn about: NHS Training, NHS health...

...This approach has provided functional insights that had not been possible with genomic studies alone, and in doing so suggested key disease drivers... Learn about: Clinical decision, Genetic abnormalities, Clinical phenotype...

...In collaboration with Dr Jeffrey Huang, Biomarker Service, we will use quantitative proteomics (10plex-ITRAQ) to compare the expression level of the cellular... Learn about: Human CLL, Chronic lymphocytic...

...signalling and endothelial dysfunction could also contribute to cardiac insulin resistance and CHF. In this research, we plan to utilize the high fat-fed...

...hypoglycaemia leads to a raising of individual thresholds (lower glucose) for the counterregulatory response (CRR) to subsequent hypoglycaemia. The principal... Learn about: Diabetes Nutrition, Diabetes Care, Severe hypoglycaemia...

...alternate treatment strategies for male factor infertility, and a demand for focussed treatment options to improve sperm motility (Barratt et... Learn about: Drug Discovery, Phenotypic Screening...

...Acute pain is intrinsically unpleasant and aversive but is useful as it has survival benefit. However, many people suffer from chronic treatment-resistant... Learn about: Chemotherapy CIPN...

...This studentship will investigate this effect further, as it may be due either to anti-hyperglycaemic effects possibly suitable for drug repurposing...

...effects of metformin are exerted irrespective of diabetes status[1, 2], through poorly understood ‘immunometabolic’ mechanisms that are different from... Learn about: IT risk, Human Disease...

...This will be complemented with cell biology in human cells (using CRISPR/Cas9 engineering and advanced microscopy techniques) to investigate their functional... Learn about: Cell Biology, Human cells...

...that the whole leptin molecule is not required for bioactivity, as a leptin fragment (leptin amino acids 116-130) mirrors the cognitive enhancing and neuroprotective...

...we demonstrated Patient Reported Outcome Measures (PROMs) provide a reliable additional dimensionality in understanding daily symptom severity in mental disorders cohorts... Learn about: Physical computing, Clinical PhD, Physical Chemistry...

...contribute to the defects seen in the A-T patients. Finally we will investigate whether ATM inhibitors (available from Astra Zeneca) can mimic the defects... Learn about: Nature Genetics...

...and integrated proteogenomic analyses to further characterise this classic subtype in SCCs across multiple anatomical sites. This proposal will investigate... Learn about: Human solid...

...SCC using machine learning algorithms (decision tree building and linear discriminant analysis). We propose to develop, optimize and validate this approach... Learn about: IT risk...

...LRRK2 mutation carriers will develop PD. This project will investigate whether two new diagnostic approaches can predict those LRRK2 mutation carriers...

...achieve reversal of NASH; resistance exercise is more sustainable and similarly effective, but again is beyond many patients due to co-morbidities...

...to combat the development of vemurafenib drug-resistance (1). We have also recently demonstrated that mutational inactivation of TGF receptors in skin...

...The project will involve cell culture, transfection, quantitative real-time PCR, immunoblotting, and immunofluorescence imaging...