University of Dundee courses

...the impracticality of seeking consent of patients, challenges of de-identification of image data, absence of non-proprietary software for efficient handling... Learn about: Research data, Data Management, Medical training...

...To test this system on serial blood samples already collected from 287 melanoma patients in NHS Tayside and subsequently to validate the assay in a large... Learn about: NHS health, NHS Training...

...However the clinical impact of this work is limited by inadequate understanding of how variations in cancer genomes cause changes to the cellular proteome... Learn about: Clinical decision, Clinical phenotype, Genetic abnormalities...

...Recent studies (including our own unpublished results) have indicated a role for mitochondrial activity as a significant regulator of cellular bioenergetics in... Learn about: Human CLL, Chronic lymphocytic...

...insulin signalling is emerging as a major factor for the development of CHF. The pathogenesis of insulin resistance in CHF is not fully understood...

...with type 1 diabetes and significantly increases their risk of severe hypoglycaemia. Since the seminal work of Heller [nearly 30 years ago we have known... Learn about: Severe hypoglycaemia, Diabetes Clinical Care, Diabetes Nutrition...

...The project will be an unrivalled opportunity for a student to learn a raft of advance biological techniques as well as gain hands-on experience with industry-standard... Learn about: Phenotypic Screening, Drug Discovery...

...pain that lasts months or years, lacks survival benefit, seriously impairs quality of life and causes unnecessary suffering. Biomarkers have been crucial... Learn about: Chemotherapy CIPN...

...The anti-inflammatory drug sulfasalazine, which is used in rheumatoid arthritis and inflammatory bowel disease, was reported earlier to suppress HbA1c...

...the student will identify and then use a suitable human cell model to investigate the relationship between amino acid metabolism and immune effects of the... Learn about: Human Disease, IT risk...

...is common to every single one of those sites: the rate of phosphorylation and dephosphorylation on individual substrate molecules. It is important to uncover this information... Learn about: Human cells, Cell Biology...

...Here we aim to use a range of model systems, including human induced pluripotent stem cell (iPSC) technologies, to mirror tau pathophysiology that occurs...

...and will be assisting in posing key questions that are useful from a practitioner’s perspective, and also in interpreting findings. Physical visits... Learn about: Physical computing, Physical Intervention, Physical Chemistry...

...Although metformin has been used in the clinic for over 60 years the molecular details of its mechanism of action remain passionately debated... Learn about: Nature Genetics...

...its molecular pathogenesis and provide new precision medicine strategies for diagnosis, prevention and treatment including novel NRF2 inhibitors as... Learn about: Human solid...

...of cancer mortality with limited therapeutic options for advanced disease. Immunotherapies such as immune checkpoint inhibitors (ICi) have changed... Learn about: IT risk...

...based on the monitoring of Rab10 phosphorylation.4 This has been shown to be a robust and novel approach to assessing LRRK2 activity. Dr Green has developed...

...Non-alcoholic steato-hepatitis (NASH) affects up to 3% of the population and leads to cirrhosis, hepatocellular carcinoma and death the only treatment is weight loss and exercise...

...Importantly, vemurafenib-resistant patient derived melanoma cells retained sensitivity to TGFBR1 inhibition, suggesting that TGFBR1 could be targeted therapeutically...

...which have a characteristic chemical signature: the ability to react with sulfhydryl groups. Using the human osteosarcoma cell line U2OS, we recently found that two Nrf2 activators...